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In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates


Chen, Bao Jing and Jamaludin, Nazzatush Shimar and Khoo, Chai Hoon and See, Tian Hong and Sim, Jiun Horng and Cheah, Yoke Kqueen and Abdul Halim, Siti Nadiah and Seng, Hoi Ling and Tiekink, Edward R.T. (2016) In vitro antibacterial and time kill evaluation of mononuclear phosphanegold(I) dithiocarbamates. Journal of Inorganic Biochemistry, 163. pp. 68-80. ISSN 0162-0134; ESSN: 1873-3344


Four compounds, R3PAu[S2CN(CH2CH2OH)2], R = Ph (1) and cyclohexyl (2), and Et3PAuS2CNRꞌ2, Rꞌ = Rꞌ = Et (3) and Rꞌ2 = (CH2)4 (4), have been evaluated for antibacterial activity against a panel of 24 Gram positive (8) and Gram negative (16) bacteria. Based on minimum inhibitory concentration (MIC) scores, compounds 1 and 2 were shown to be specifically potent against Gram positive bacteria whereas compounds 3 and, to a lesser extent, 4 exhibited broad range activity. All four compounds were active against methicillin resistant Staphylococcus aureus (MRSA). Time kill assays revealed the compounds to exhibit both time- and concentration-dependent pharmacokinetics against susceptible bacteria. Each compound was bactericidal against one or more bacteria with 3 being especially potent after 8 h exposure; compounds 1 and 3 were bactericidal against MRSA. Compound 3 was the most effective bactericide across the series especially toward B. subtilis, S. saprophyticus, A. hydrophila, P. vulgaris, and V. parahaemolyticus. This study demonstrates the potential of this class of compounds as antibacterial agents, either broad range or against specific bacteria.

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Additional Metadata

Item Type: Article
Subject: Phosphanegold(I) compounds; Dithiocarbamate; Thiolate; Antimicrobial; Time kill assay
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1016/j.jinorgbio.2016.08.002
Publisher: Elsevier
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 27 Mar 2018 04:29
Last Modified: 27 Mar 2018 04:29
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.jinorgbio.2016.08.002
URI: http://psasir.upm.edu.my/id/eprint/54533
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