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Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia


Citation

Abdul Aziz, Zariah and Lee, Yvonne Y. L. and Sidek, Norsima Nazifah and Awang Ngah, Bahari and Looi, Irene and Hanip, Md.Rafia and Basri, Hamidon (2016) Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia. Neurological Research, 38 (5). pp. 406-413. ISSN 0161-6412; ESSN: 1743-1328

Abstract / Synopsis

Objective: Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke. Methods: Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed. Results: A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender–age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis. Discussion: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.


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Additional Metadata

Item Type: Article
Subject: Gender; Disparities; Predictor; Clinical; Registry; Ischemic
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1080/01616412.2016.1178948
Publisher: Taylor & Francis
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 14 Mar 2018 15:21
Last Modified: 14 Mar 2018 15:21
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/01616412.2016.1178948
URI: http://psasir.upm.edu.my/id/eprint/54369
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