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Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes


Citation

Moradipoor, Sara and Ismail, Patimah and Etemad, Ali and Wan Sulaiman, Wan Aliaa and Ahmadloo, Salma (2016) Expression profiling of genes related to endothelial cells biology in patients with type 2 diabetes and patients with pre-diabetes. BioMed Research International, 2016. art. no. 1845638. pp. 1-12. ISSN 2314-6133; ESSN: 2314-6141

Abstract

Endothelial dysfunction appears to be an early sign indicating vascular damage and predicts the progression of atherosclerosis and cardiovascular disorders. Extensive clinical and experimental evidence suggests that endothelial dysfunction occurs in Type 2 Diabetes Mellitus (T2DM) and prediabetes patients. This study was carried out with an aim to appraise the expression levels in the peripheral blood of 84 genes related to endothelial cells biology in patients with diagnosed T2DM or prediabetes, trying to identify new genes whose expression might be changed under these pathological conditions. The study covered a total of 45 participants. The participants were divided into three groups: group 1, patients with T2DM; group 2, patients with prediabetes; group 3, control group. The gene expression analysis was performed using the Endothelial Cell Biology RT2 Profiler PCR Array. In the case of T2DM, 59 genes were found to be upregulated, and four genes were observed to be downregulated. In prediabetes patients, increased expression was observed for 49 genes, with two downregulated genes observed. Our results indicate that diabetic and prediabetic conditions change the expression levels of genes related to endothelial cells biology and, consequently, may increase the risk for occurrence of endothelial dysfunction.


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Additional Metadata

Item Type: Article
Subject: Profiling of genes; Endothelial cells biology; Type 2 diabetes; Pre-diabetes
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1155/2016/1845638
Publisher: Hindawi Publishing Corporation
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 08 Mar 2018 07:39
Last Modified: 08 Mar 2018 07:39
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2016/1845638
URI: http://psasir.upm.edu.my/id/eprint/54249
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