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Spontaneous autologous erythrocyte-rosette formation of lymphocytes from cerebrospinal fluid of a dog with canine distemper.


Citation

N. A. B. Y., Cheng and K. M., Tham (1991) Spontaneous autologous erythrocyte-rosette formation of lymphocytes from cerebrospinal fluid of a dog with canine distemper. Jurnal Veterinar Malaysia, 3 (1). pp. 1-6.

Abstract / Synopsis

An adult female crossbed dog, with pyrexia, ocular, neurologic and respiratory problems suggestive of distemper, was observed for 28 days. Marked lymphopenia was present on days, 8, 12, and 245, and myoclonus of the fore- and hind-limbs was seen on day 22. At day 24, a cytopahogenic agent with paramyxovirus morphology was isolated from peripheral blood mononuclear cells by co-cultivation with Vero cells. On day 28, cerebrospinal fluid was found to contain 82.7% of lymphocytes and 10% monocytes. About 19% of these lymphocytes formed spontaneous autologous erythrocyte-rosettes. The demonstration of such rosettes (at 4-5 times the level normal for dogs) is unusual. It is possible that is rosette test may be specific for distemper infection. This technique must be further investigated to determine if it can be used as a specific diagnostic test for distemper in dogs.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Keywords: Distemper, erythocyte-rosettes
Depositing User: Azizan Arshad
Date Deposited: 08 Apr 2010 04:43
Last Modified: 22 Dec 2015 08:11
URI: http://psasir.upm.edu.my/id/eprint/5315
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