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Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins


Sahebi, Mahbod and Musa, Mohamed Hanafi and Wijnen, Andre J. van and Azizi, Parisa and Abiri, Rambod and Ashkani, Sadegh and Taheri, Sima (2016) Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins. Gene, 587 (2). pp. 107-119. ISSN 0378-1119; ESSN: 1879-0038

Abstract / Synopsis

Alternative pre-mRNA splicing provides a source of vast protein diversity by removing non-coding sequences (introns) and accurately linking different exonic regions in the correct reading frame. The regulation of alternative splicing is essential for various cellular functions in both pathological and physiological conditions. In eukaryotic cells, this process is commonly used to increase proteomic diversity and to control gene expression either co- or post-transcriptionally. Alternative splicing occurs within a megadalton-sized, multi-component machine consisting of RNA and proteins; during the splicing process, this complex undergoes dynamic changes via RNA–RNA, protein–protein and RNA–protein interactions. Co-transcriptional splicing functionally integrates the transcriptional machinery, thereby enabling the two processes to influence one another, whereas post-transcriptional splicing facilitates the coupling of RNA splicing with post-splicing events. This review addresses the structural aspects of spliceosomes and the mechanistic implications of their stepwise assembly on the regulation of pre-mRNA splicing. Moreover, the role of phosphorylation-based, signal-induced changes in the regulation of the splicing process is demonstrated.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Biotechnology and Biomolecular Sciences
Institute of Tropical Agriculture
DOI Number:
Publisher: Elsevier
Keywords: Pre-mRNA splicing; Post-transcriptional splicing; Co-transcriptional splicing; Post-transcriptional splicing; SR proteins
Depositing User: Nabilah Mustapa
Date Deposited: 06 Jun 2017 16:44
Last Modified: 06 Jun 2017 16:44
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