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In vitro larvicidal effects of ethanolic extract of Curcuma longa Linn. on Haemonchus larval stage


Nasai, Norisal and Abba, Yusuf and Abdullah, Faez Firdaus Jesse and Marimuthu, Murugaiyah and Tijjani, Abdulnasir and Sadiq, Muhammad Abubakar and Mohammed, Konto and Lim, Eric Teik Chung and Omar, Mohamed Ariff (2016) In vitro larvicidal effects of ethanolic extract of Curcuma longa Linn. on Haemonchus larval stage. Veterinary World, 9 (4). pp. 417-420. ISSN 0972-8988; ESSN: 2231-0916


Aim: Gastrointestinal helminthosis is a global problem in small ruminant production. Most parasites have developed resistance to commonly available anthelminthic compounds, and there is currently an increasing need for new compounds with more efficacies. This study evaluated the in vitro effects of ethanolic extract of Curcuma longa (EECL) as a biological nematicide against third stage Haemonchus larvae (L3) isolated from sheep. Materials and Methods: Haemonchus L3 were cultured and harvested from the feces of naturally infected sheep. EECL was prepared and three concentrations; 50, 100, and 200 mg/mL were tested for their efficacies on Haemonchus L3. Levamisole at concentration 1.5 and 3 mg/mL were used as positive controls. Results: EECL showed anthelmintic activity in a dose-dependent manner with 78% worm mortality within 24 h of exposure at the highest dose rate of 200 mg/mL. There was a 100% worm mortality rate after 2 h of levamisole (3 mg/mL) admisntration. However, there was a comparable larvicidal effect between when levamisole (1.5 mg/mL) and EECL (200 mg) were administered. Conclusion: The study shows that EECL does exhibit good anthelmintic properties at 200 mg/mL which is comparable with levamisole at 1.5 mg/mL.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Veterinary World
Keywords: Curcuma longa; Ethanolic extract; Haemonchus; Larvae 3; Levamisole; Strongyle
Depositing User: Nabilah Mustapa
Date Deposited: 06 Jun 2017 08:28
Last Modified: 06 Jun 2017 08:28
URI: http://psasir.upm.edu.my/id/eprint/52406
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