UPM Institutional Repository

Hypocholesterolemic and antiatherosclerotic potential of Basella alba leaf extract in hypercholesterolemia-induced rabbits


Gunasekaran, Baskaran and Salvamani, Shamala and Azlan, Azrina and Ahmad, Siti Aqlima and Yeap, Swee Keong and Abd. Shukor, Mohd. Yunus (2015) Hypocholesterolemic and antiatherosclerotic potential of Basella alba leaf extract in hypercholesterolemia-induced rabbits. Evidence-Based Complementary and Alternative Medicine, 2015. art. no. 751714. pp. 1-7. ISSN 1741-427X; ESSN: 1741-4288


Hypercholesterolemia is the major risk factor that leads to atherosclerosis. Nowadays, alternative treatment using medicinal plants gained much attention since the usage of statins leads to adverse health effects, especially liver and muscle toxicity. This study was designed to investigate the hypocholesterolemic and antiatherosclerotic effects of Basella alba (B. alba) using hypercholesterolemia-induced rabbits. Twenty New Zealand white rabbits were divided into 5 groups and fed with varying diets: normal diet, 2% high cholesterol diet (HCD), 2% HCD + 10 mg/kg simvastatin, 2% HCD + 100 mg/kg B. alba extract, and 2% HCD + 200 mg/kg B. alba extract, respectively. The treatment with B. alba extract significantly lowered the levels of total cholesterol, LDL, and triglycerides and increased HDL and antioxidant enzymes (SOD and GPx) levels. The elevated levels of liver enzymes (AST and ALT) and creatine kinase were noted in hypercholesterolemic and statin treated groups indicating liver and muscle injuries. Treatment with B. alba extract also significantly suppressed the aortic plaque formation and reduced the intima: media ratio as observed in simvastatin-treated group. This is the first in vivo study on B. alba that suggests its potential as an alternative therapeutic agent for hypercholesterolemia and atherosclerosis.

Download File

[img] PDF
Restricted to Repository staff only

Download (1MB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2015/751714
Publisher: Hindawi Publishing Corporation
Keywords: Hypocholesterolemic; Antiatherosclerotic; Basella alba; Rabbits
Depositing User: Nabilah Mustapa
Date Deposited: 05 Jun 2017 09:15
Last Modified: 05 Jun 2017 09:15
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2015/751714
URI: http://psasir.upm.edu.my/id/eprint/52322
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item