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Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure


Kanagesan, Samikannu and Hashim, Mansor and Subramani, Tamilselvan and Mohammed Alitheen, Noorjahan Banu and Ismail, Ismayadi and Bahmanrokh, Ghazaleh (2013) Cytotoxic effect of nanocrystalline MgFe2O4 particles for cancer cure. Journal of Nanomaterials, 2013. art. no. 865024. pp. 1-8. ISSN 1687-4110; ESSN: 1687-4129


Nanocrystalline magnesium ferrites (MgFe2O4) were produced with an average grain size of about 20 nm. Their structural, morphological, and magnetic characterizations were studied. The cytotoxic effects of MgFe2O4 nanoparticles in various concentrations (25, 50, 100, 200, 400, and 800 μg/mL) against MCF-7 human breast cancer cells were analyzed. MTT assay findings suggest the increased accumulation of apoptotic bodies with the increasing concentration of MgFe2O4 nanoparticles in a dose-dependent manner. Flow cytometry analysis shows that MgFe2O4 nanoparticles in 800 μg/mL concentration are more cytotoxic compared to vehicle-treated MCF-7 cells and suggests their potential utility as a drug carrier in the treatment of cancer.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Advanced Technology
DOI Number: https://doi.org/10.1155/2013/865024
Publisher: Hindawi Publishing Corporation
Keywords: MgFe2O4; Magnesium ferrite; Breast cancer; Cytotoxic effect; Cancer treatment
Depositing User: Nabilah Mustapa
Date Deposited: 05 Jun 2017 05:05
Last Modified: 05 Jun 2017 05:05
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2013/865024
URI: http://psasir.upm.edu.my/id/eprint/52210
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