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Sol-gel auto-combustion synthesis of cobalt ferrite and it's cytotoxicity properties


Citation

Kanagesan, Samikannu and Hashim, Mansor and Subramani, Tamilselvan and Mohammed Alitheen, Noorjahan Banu and Ismail, Ismayadi and Mustaffa, Muhammad Syazwan and Muhammad Zulkimi, Muhammad Misbah (2013) Sol-gel auto-combustion synthesis of cobalt ferrite and it's cytotoxicity properties. Digest Journal of Nanomaterials and Biostructures, 8 (4). pp. 1601-1610. ISSN 1842-3582

Abstract

Cobalt ferrite (CoFe2O4) nanoparticles were successfully synthesized by a sol-gel combustion technique. The particle size as determined by a transmission electron microscope was about 25 nm. A maximum saturation magnetization of 22.31 emu/g and a coercivity of 118 Oe were achieved for the samples. The effect of CoFe2O4 nanoparticles on 4T1 murine breast cancer cells was explored by cytotoxicity assay and flow cytometer analysis. The lower concentrations of CoFe2O4 nanoparticles did not induce any toxicity in cells, when exposed for 24 h. Concentrations exceeding 400 μg/ml produced significant morphological changes and induced cell death by apoptosis and necrosis.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Advanced Technology
Publisher: National Institute R&D Materials Physics
Keywords: Cobalt; Magnetization; Phase formation; Sol-gel
Depositing User: Nabilah Mustapa
Date Deposited: 05 Jun 2017 05:03
Last Modified: 05 Jun 2017 05:03
URI: http://psasir.upm.edu.my/id/eprint/52188
Statistic Details: View Download Statistic

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