Citation
Abstract
Background: There is little information on the effects of diets containing high α-linolenic acid (C18:3n-3) on liver lipid composition and lipogenic gene expressions. In this study fourteen goats (Capra aegagrus hircus) were fed either a flaxseed oil (FSO) supplemented diet containing high α-linolenic acid or a control diet without added flaxseed oil (CON) for 100-d to evaluate the effects on liver lipid composition and the gene expression of peroxisome proliferator-activated receptors (PPAR-α) and stearoyl-CoA-desaturase (SCD) in the liver. Results: An increase in the levels of C18:3n-3 and C20:5n-3, C22:5n-3, C22:6n-3 was observed in the liver of FSO-treated goats. There was a significant (P < 0.05) up-regulation of PPAR-α gene expression and downregulation of SCD gene in the liver of goats fed the high α-linolenic acid diet. Conclusions: In conclusion, genes associated with the control of fatty acid (FA) conversion (SCD and PPAR) were affected by the α-linolenic acid supplementation in the goat diet. It is suggested that PPAR-α is the key messenger responsible for the translation of nutritional stimuli into changes in hepatic gene expression.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Veterinary Medicine Institute of Tropical Agriculture |
| DOI Number: | https://doi.org/10.1016/j.ejbt.2015.03.009 |
| Publisher: | Pontificia Universidad Católica de Valparaíso |
| Keywords: | Gene expression; Goat; Liver; Omega-3 fatty acid; PPAR |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 04 May 2017 09:00 |
| Last Modified: | 04 May 2017 09:00 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.ejbt.2015.03.009 |
| URI: | http://psasir.upm.edu.my/id/eprint/52022 |
| Statistic Details: | View Download Statistic |
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