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Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling


Noor, Hamdan and Ashcroft, Stephen J. H. (1998) Insulinotropic activity of Tinospora crispa extract: effect on ß-cell Ca2+ handling. Phytotherapy Research, 12 (2). pp. 98-102. ISSN 0951-418X; ESSN: 1099-1573


The mechanism of insulinotropic action of Tinospora crispa was investigated in vitro using an insulin-secreting clonal β-cell line, HIT-T15. The aqueous extract sensitizes the β-cell to extracellular Ca2+ and promotes intracellular Ca2+ accumulation which in turn causes increased insulin release. The increase in cytosolic Ca2+ concentration is due to stimulation of Ca2+ uptake from the extracellular medium and inhibition of Ca2+ efflux from the cytosol. That the mechanism of insulinotropic action of T. crispa is physiological suggests that the insulin secretagogue/s present in the extract could indeed be a potential source of a specific oral hypoglycaemic agent for the treatment of non-insulin-dependent diabetes mellitus.

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Additional Metadata

Item Type: Article
Divisions: Universiti Putra Malaysia
DOI Number: https://doi.org/10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F
Publisher: John Wiley & Sons
Keywords: β-cell; Ca2+; Diabetes mellitus; Insulin secretion; Insulinotropic; Tinospora crispia
Depositing User: Nabilah Mustapa
Date Deposited: 06 Sep 2017 07:52
Last Modified: 06 Sep 2017 07:52
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/(SICI)1099-1573(199803)12:2<98::AID-PTR195>3.0.CO;2-F
URI: http://psasir.upm.edu.my/id/eprint/51742
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