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Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts


Citation

A. G., Siti Zulaikha and Mediani, Ahmed and Khoo, L. W. and Lee, S. Y. and Leong, S. W. and Abas, Faridah (2017) Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts. International Food Research Journal, 24 (1). pp. 114-120. ISSN 1985-4668; ESSN: 2231-7546

Abstract / Synopsis

The main purpose of this study was to evaluate the antioxidant and α-glucosidase inhibitory activities of Phyllanthus acidus. The P. acidus fruits were dried using three different methods, namely oven (OD), air (AD) and freeze (FD) dryings and extracted with ethanol at different ratios (50 and 100%). The proximate analysis and total phenolic content (TPC) as well as free radical scavenging and α-glucosidase inhibitory activities were determined. The proximate analysis of P. acidus fruit indicated that all the dried samples contained potential nutrient contents. The highest TPC value, α-glucosidase inhibitory and antioxidant activities were observed for 50% ethanolic extract from OD method with TPC value of 28.39 mg GAE/g dried extract, IC50 value of 12.394 μg/mL and 64.17% inhibition, respectively. The study revealed that phenolic compounds could be the main contributors to the antioxidant and α-glucosidase inhibitory activities based on the Pearson correlation coefficients with R values of 95.0 and 73.8%, respectively. The study could provide scientific evidence for some folk uses in the treatment of diseases related to the production of reactive oxygen species and oxidative stress.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Institute of Bioscience
Publisher: Faculty of Food Science and Technology, Universiti Putra Malaysia
Keywords: Phyllantus acidus; Drying methods; Proximate analysis; Free radical scavenging activity; α-Glucosidase inhibitory activity
Depositing User: Nabilah Mustapa
Date Deposited: 27 Apr 2017 17:55
Last Modified: 27 Apr 2017 17:55
URI: http://psasir.upm.edu.my/id/eprint/51677
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