Xanthones from Calophyllum inophyllum

Citation

Lee, Kar Wei and Ee, Gwendoline Cheng Lian and Daud, Shaari and Karunakaran, Thiruventhan (2017) Xanthones from Calophyllum inophyllum. Pertanika Journal of Tropical Agricultural Science, 40 (1). pp. 111-118. ISSN 1511-3701; ESSN: 2231-8542

Abstract

Repeated separation and purification of fractions from the crude chloroform extract of Calophyllum inophyllum via column chromatography afforded five known xanthone caloxanthones A, B, C, macluraxanthone and pyranojacareubin. Structural elucidations and determination of the isolated compounds were supported by spectral analyses obtained by subjecting the compounds to various spectroscopic techniques. The chloroform extract, when tested against RAW264.7 cells for anti-inflammatory potentials, exhibited the most promising activity with an IC50 value of 14.81±0.04 µg/mL compared to moderate activities shown by the ethyl acetate and n-hexane extracts. Antimicrobial tests showed that the n-hexane and chloroform extracts acted moderately against Staphylococcus epidermidis S273 and Bacillus subtilis B145.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Science
Publisher:	Universiti Putra Malaysia Press
Keywords:	Anti-inflammatory; Antimicrobial; Calophyllum inophyllum; Xanthones
Depositing User:	Nabilah Mustapa
Date Deposited:	05 Apr 2017 05:27
Last Modified:	05 Apr 2017 05:27
URI:	http://psasir.upm.edu.my/id/eprint/51636
Statistic Details:	View Download Statistic

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