UPM Institutional Repository

Nutrigenomic effects of Curculigo latifolia on type 2 diabetic model


Ishak, Nur Akmal and Ismail, Maznah (2015) Nutrigenomic effects of Curculigo latifolia on type 2 diabetic model. In: Persidangan Industri Herba 2015, 3-5 Nov. 2015, Putrajaya. (pp. 264-273).


The present study evaluated the anti-diabetic effects of Curculigo latifolia fruit:root. The hypoglycemic and hypolipidemic effects of C. latifolia fruit:root were investigated in high fat diet (HFD) with combination of low dose streptozotocin (STZ, 40 mg/kg body weight (b.w)) induced diabetic rats. C. latifolia fuit:root was orally administered once a day at 50, 100 and 200 mg/kg b.w for 30 days. Before and after treatments, plasma glucose, lipid and insulin were measured. The nutrigenomic effects of C. latifolia fruit:root extracts on genes involved in glucose and lipid metabolisms were further studied on glucose transporter (GLUT 4), leptin (LEP) and insulin receptor substrate 1 (IRS1) in adipose tissues. Results showed that 200 mg/kg b.w of C. latifolia fruit:root extracts significantly reduced blood glucose and plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL) levels. Meanwhile, insulin and high density lipoprotein-cholesterol (HDL) were increased. In addition, C. latifolia fruit:root extracts also increased the regulation of GLUT 4 (1 fold), Lep (3 fold) and IRS1 (2 fold) in adipose tissues. The results suggest that C. latifolia possess significant hypoglycemic and hypolipidemic effects. Hence, C. latifolia can be used as functional food or incorporated as a supplement in health-care food for the treatment of type 2 diabetic.

Download File

[img] PDF
Restricted to Repository staff only

Download (730kB)

Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
Publisher: Institut Penyelidikan Perhutanan Malaysia
Keywords: Curculigo latifolia; Gene expression; High fat fed diet; Insulin; Type 2 diabetes mellitus
Depositing User: Nabilah Mustapa
Date Deposited: 04 Apr 2017 03:36
Last Modified: 04 Apr 2017 03:36
URI: http://psasir.upm.edu.my/id/eprint/51386
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item