Citation
Ali, Abdul Manaf and Ismail, Intan Safinar and Mohamed Mackeen, Muhammad Mukram and El-Sharkawy, Saleh Hassan and Takahata, Kyoya and Kanzaki, Hiroshi and Kawazu, Kazuyoshi
(1998)
Bioassay-guided isolation of deoxypodophyllotoxin, the cytotoxic constituent of Juniperus chinensis.
Natural Product Sciences, 4 (3).
pp. 180-183.
ISSN 1226-3907
Abstract
The ethanol extract from the leaves of Juniperus chinensis was found to be cytotoxic towards HeLa cells. Bioassay-guided fractionation of the EtOAc soluble faction directed by the microtitration cytotoxic assay revealed that the cytotoxic compound was deoxypodophyllotoxin. All the tumour cell lines tested (KU8112F-chronic mylogeneous leukemia, TK 10-renal carcinoma, UACC 62-melanoma and CEM-SS - T-lymphoblastic leukemia) were found to be susceptible to deoxypodophyllotoxin, however, the minimum effective concentration (MEC) required to reduce the cell population by 100 percent was different between cell lines.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Food Science and Biotechnology |
| Publisher: | Korean Society of Pharmacognosy |
| Keywords: | Cytotoxicity; Deoxypodophyllotoxin; Juniperus chinensis |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 04 Jul 2017 03:56 |
| Last Modified: | 04 Jul 2017 03:56 |
| URI: | http://psasir.upm.edu.my/id/eprint/51340 |
| Statistic Details: | View Download Statistic |
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