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The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in Nubian goats


Citation

Elsheikh, Hatim Ali and Osman, I. A. M. and Abdullah, A. S. (1997) The effect of water deprivation on the pharmacokinetics of antipyrine and sulphadimidine following intravenous administration in Nubian goats. Veterinary Research Communications, 21 (8). pp. 587-597. ISSN 0165-7380; ESSN: 1573-7446

Abstract / Synopsis

The effect of water deprivation on the pharmacokinetic parameters of antipyrine and sulphadimidine in the Nubian goat was studied. Water deprivation, to a level of dehydration at which the animals lost an average of 7.5% body weight, resulted in a significant reduction in antipyrine clearance (p < 0.05), and a consequently increased AUC value (p < 0.05). No effect was observed on the distribution parameters of the drug. In dehydrated animals which had lost an average of 10% or 12.5% of their body weight owing to water deprivation, significant changes were found in the distribution and elimination pharmacokinetic parameters of antipyrine and sulphadimidine. The volume of distribution was significantly decreased, resulting n elevated plasma levels for the two drags compared to normally watered animals. Significant decreases in clearance and subsequent prolongation of the elimination half-lives were observed during these periods of water deprivation. These changes in the disposition kinetics of the two drugs may be attributed to the loss of total body water and extracellular fluids and changes in the liver and kidney functions taking place during dehydration.


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Additional Metadata

Item Type: Article
Divisions: Universiti Putra Malaysia
DOI Number: https://doi.org/10.1023/A:1005975016275
Publisher: Kluwer Academic Publishers
Keywords: Antipyrine; Dehydration; Goats; Pharmacokinetics; Sulphadimidine
Depositing User: Nabilah Mustapa
Date Deposited: 02 May 2017 12:07
Last Modified: 02 May 2017 12:07
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1023/A:1005975016275
URI: http://psasir.upm.edu.my/id/eprint/51050
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