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Antitrypanosomal activities of selected medicinal plants


Dyary, Hiewa O. and Abdul Kadir, Arifah and Kumar Sharma, Reuben Sunil and Abdullah, Rasedee and Md. Sukari, Mohd Aspollah and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul (2012) Antitrypanosomal activities of selected medicinal plants. In: International Conference on One Health and 24th VAM Congress 2012, 21-23 Sept. 2012, Marriott Putrajaya. (pp. 386-388).


The aqueous and ethanolic extracts from four medicinal plants namely Acanthus ilicifolius, Aquilaria malaccensis, Goniothalamus tapis, and Maesa ramentacea, were tested in vitro against Trypanosoma evansi, a hemoprotozoan parasite causing surra in a vast variety of domesticated and wild animals. The antitrypanosomal activity was evaluated by calculating median inhibitory concentration (IC50), the concentration that gives half maximal growth of the trypanosomes, of the plant extracts. Goniothalamus tapis ethanolic extract showed the most potent antitrypanosomal activity with an IC50 value of 7.6 ± 1.6 μg ml-1. The other extracts scored IC50 values ranging from 36.2 ± 1.3 μg ml-1 to 314.1 ± 37.1 μg ml-1.

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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Faculty of Veterinary Medicine
Keywords: Trypanosoma evansi; Surra; Medicinal plants; Antitrypanosomal activity; Median inhibitory concentration
Depositing User: Nabilah Mustapa
Date Deposited: 01 Mar 2017 09:38
Last Modified: 01 Mar 2017 09:38
URI: http://psasir.upm.edu.my/id/eprint/50244
Statistic Details: View Download Statistic

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