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Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals


Citation

Zakaria, Zainul Amiruddin and Loo, Yi Wen and Abdul Rahman, Nurul Izzah and Abdul Ayub, Abdul Halim and Sulaiman, Mohd Roslan and Gopalan, Hanan Kumar (2007) Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals. Medical Principles and Practice, 16 (6). pp. 443-449. ISSN 1011-7571; ESSN: 1423-0151

Abstract

Objective: The present study was carried out to determine the antinociceptive, anti-inflammatory and antipyretic activities of the aqueous extract of Bauhinia purpurea leaves using animal models. Materials and Methods: The air-dried, powdered leaves (≈20 g) were soaked in distilled water (1:20; w/v) at room temperature for 72 h and the supernatant obtained was freeze-dried. The crude dried extract (≈2.4 g) was prepared in doses of 6.0, 30.0 and 60.0 mg/kg, and subjected to the respective antinociceptive (abdominal constriction, hot plate and formalin tests), anti-inflammatory (carrageenan-induced paw edema test) and antipyretic (brewer's yeast-induced pyrexia test) assays. Results:The results obtained indicate that the extract possessed significant (p < 0.05) antinociceptive, anti-inflammatory and antipyretic activities, which were not dependent on the doses of extract used. The highest concentration of extract was less effective as an anti-inflammatory and an antipyretic agent. Conclusion: This study showed that the aqueous extract of B. purpurea leaves possesses potential pharmacological activities that require further investigation and, thus, confirms the folklore use of the plant in the treatment of ailments associated with pain and inflammation.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1159/000107749
Publisher: S. Karger AG
Keywords: Anti-inflammatory; Antinociceptive; Antipyretic; Aqueous extract; Bauhinia purpurea
Depositing User: Nabilah Mustapa
Date Deposited: 10 Oct 2016 03:43
Last Modified: 10 Oct 2016 03:43
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1159/000107749
URI: http://psasir.upm.edu.my/id/eprint/48585
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