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Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals


Citation

Zakaria, Zainul Amiruddin and Raden Mohd Nor, Raden Nur Suraya and Gopalan, Hanan Kumar and Abdul Ghani, Zuleen Delina Fasya and Sulaiman, Mohd Roslan and Ganeson, Rathna Devi and Mat Jais, Abdul Manan and Somchit, Muhammad Nazrul and Abdullah, Fatimah Corazon (2006) Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals. Canadian Journal of Physiology and Pharmacology, 84 (12). pp. 1291-1299. ISSN 0008-4212; ESSN: 1205-7541

Abstract

The present study was carried out to establish the antinociceptive, anti-inflammatory, and antipyretic properties of the aqueous extract of Melastoma malabathricum leaves in experimental animals. The antinociceptive activity was measured using abdominal constriction, hot-plate, and formalin tests, whereas the anti-inflammatory and antipyretic activities were measured using carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests, respectively. The extract, which was obtained after soaking the air-dried leaves in distilled water for 72 h and then preparing in concentrations of 10%, 50%, and 100% (v/v), was administered subcutaneously 30 min prior to subjection to the above mentioned assays. At all concentrations tested, the extract was found to exhibit significant (P < 0.05) antinociceptive, anti-inflammatory, and antipyretic activities in a concentration-independent manner. Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1139/y06-083
Publisher: NRC Research Press
Keywords: Anti-inflammatory; Antinociceptive; Antipyretic; Aqueous extract; Melastoma malabathricum
Depositing User: Nabilah Mustapa
Date Deposited: 10 Oct 2016 03:43
Last Modified: 23 Jul 2020 00:55
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1139/y06-083
URI: http://psasir.upm.edu.my/id/eprint/48579
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