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The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis


Ochieng, Josiah and Nangami, Gladys N. and Ogunkua, Olugbemiga and Miousse, Isabelle R. and Koturbash, Igor and Marah, Valerie Odero and McCawley, Lisa J. and Makker, Pratima Nangie and Ahmed, Nuzhat and Luqmani, Yunus and Zhenbang, Chen and Papagerakis, Silvana and Wolf, Gregory T. and Dong, Chenfang and Zhou, Binhua P. and Brown, Dustin G. and Colacci, Annamaria and Hamid, Roslida A. and Mondello, Chiara and Raju, Jayadev and Ryan, Elizabeth P. and Woodrick, Jordan and Scovassi, Ivana and Singh, Neetu and Vaccari, Monica and Roy, Rabindra and Forte, Stefano and Memeo, Lorenzo and Salem, Hosni K. and Amedei, Amedeo and Al-Temaimi, Rabeah and Al-Mulla, Fahd and Bisson, William H. and Eltom, Sakina E. (2015) The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis, 36 (suppl.). pp. 128-159. ISSN 0143-3334; ESSN: 1460-2180


The purpose of this review is to stimulate new ideas regarding low-dose environmental mixtures and carcinogens and their potential to promote invasion and metastasis. Whereas a number of chapters in this review are devoted to the role of low-dose environmental mixtures and carcinogens in the promotion of invasion and metastasis in specific tumors such as breast and prostate, the overarching theme is the role of low-dose carcinogens in the progression of cancer stem cells. It is becoming clearer that cancer stem cells in a tumor are the ones that assume invasive properties and colonize distant organs. Therefore, low-dose contaminants that trigger epithelial-mesenchymal transition, for example, in these cells are of particular interest in this review. This we hope will lead to the collaboration between scientists who have dedicated their professional life to the study of carcinogens and those whose interests are exclusively in the arena of tissue invasion and metastasis.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1093/carcin/bgv034
Publisher: Oxford University Press
Keywords: Cancer; Epithelium; Carcinogens; Neoplasm metastasis; Neoplasms
Depositing User: Nida Hidayati Ghazali
Date Deposited: 26 Feb 2018 02:55
Last Modified: 26 Feb 2018 02:55
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1093/carcin/bgv034
URI: http://psasir.upm.edu.my/id/eprint/46611
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