Citation
Wahyuni, Fatma Sri and Lim, Siang Hui and Stanslas, Johnson and Lajis, Nordin and Hamidi, Dachriyanus
(2015)
Tetraprenyltoluquinone, an anticancer compound from Garcinia cowa Roxb induce cell cycle arrest on H460 non small lung cancer cell line.
International Journal of Pharmaceutical Sciences Review and Research, 32 (2).
art. no. 27.
pp. 166-168.
ISSN 0976-044X
Abstract
Tetraprenyltoluquinone (TPTQ), isolated compound from stem bark of Garcinia cowa Roxb showed selective cytotoxicity towards H460 lung cancer cell line. We further investigated the ability of this compound in inducing cell cycle arrest by flow cytometry. Cell cycle analysis revealed that TPTQ caused cell cycle arrest in G0/G1 phase. Our results indicate that TPTQ induces cell cycle arrest and apoptosis in H-460 cells, suggesting that it might represent a potential new chemotherapeutic agent.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Institute of Bioscience |
| Publisher: | Global Research Online Publishing House |
| Keywords: | Tetraprenyltoluquinone; Garcinia cowa Roxb; Cell cycle analysis; Lung cancer; Flowcytometry |
| Depositing User: | Ms. Ainur Aqidah Hamzah |
| Date Deposited: | 20 Jun 2022 03:48 |
| Last Modified: | 20 Jun 2022 03:48 |
| URI: | http://psasir.upm.edu.my/id/eprint/46511 |
| Statistic Details: | View Download Statistic |
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