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Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles


Yap, Taufiq Yun Hin and Abdullah, Rasedee and Mftah, Ae and Alhassan, Fatah H. and El Zowalaty, Mohamed Ezzat and Webster, Thomas Jay and Sh-Eldin, Mohammed Ali and Rashid, Shah Samiur and Al-Qubaisi, Mothanna Sadiq (2015) Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles. International Journal of Nanomedicine, 10. pp. 765-774. ISSN 1178-2013; ESSN: 1176-9114


Nanoparticle sulphated zirconia with Brønsted acidic sites were prepared here by an impregnation reaction followed by calcination at 600°C for 3 hours. The characterization was completed using X-ray diffraction, thermal gravimetric analysis, Fourier transform infrared spectroscopy, Brunner-Emmett-Teller surface area measurements, scanning electron microscopy with energy dispersive X-ray spectroscopy, and transmission electron microscopy. Moreover, the anticancer and antimicrobial effects were investigated for the first time. This study showed for the first time that the exposure of cancer cells to sulphated zirconia nanoparticles (3.9–1,000 μg/mL for 24 hours) resulted in a dose-dependent inhibition of cell growth, as determined by (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Similar promising results were observed for reducing bacteria functions. In this manner, this study demonstrated that sulphated zirconia nanoparticles with Brønsted acidic sites should be further studied for a wide range of anticancer and antibacterial applications.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.2147/IJN.S66058
Publisher: Dove Medical Press
Keywords: Sulphated zirconia; Nanoparticles; Antimicrobial; Anticancer
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 21 Jan 2021 16:27
Last Modified: 21 Jan 2021 16:27
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2147/IJN.S66058
URI: http://psasir.upm.edu.my/id/eprint/45852
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