Citation
Higuchi, Akon and Ling, Qing Dong and Kumar, S. Suresh and Yung, Chang and Alarfaj, Abdullah A. and Munusamy, Murugan A. and Murugan, Kadarkarai and Hsu, Shih Tien and Umezawa, Akihiro
(2015)
Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells.
Journal of Materials Chemistry B: Materials for biology and medicine, 3 (41).
pp. 8032-8058.
ISSN 2050-750X; ESSN: 2050-7518
Abstract
Both human pluripotent stem cells (hPSCs) from embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have the potential ability to differentiate into many different cell types originating from all three germ layers. This review discusses physical cues from natural and synthetic biomaterials that guide the differentiation of hESCs and hiPSCs into several different lineages. We place special focus on how the hPSC differentiation fate is affected by (a) the elasticity of biomaterials used for hPSC culture, (b) the topography of biomaterials used for hPSC culture, and (c) the mechanical forces associated with biomaterials (stretching and electrical stimulation via biomaterials) used for hPSC culture.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| DOI Number: | https://doi.org/10.1039/c5tb01276g |
| Publisher: | Royal Society of Chemistry |
| Keywords: | Pluripotent stem cells; Embryonic stem cells; human pluripotent stem cells; Induced pluripotent stem cells |
| Depositing User: | Ms. Nuraida Ibrahim |
| Date Deposited: | 06 May 2021 00:00 |
| Last Modified: | 06 May 2021 00:00 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1039/c5tb01276g |
| URI: | http://psasir.upm.edu.my/id/eprint/45850 |
| Statistic Details: | View Download Statistic |
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