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In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract


Dyary, Hiewa O. and Abd. Kadir, Arifah and Sharma, Reuben Sunil Kumar and Abdullah, Rasedee and Md. Sukari, Mohd Aspollah and Zakaria, Zainul Amiruddin and Ahmad, Zuraini and Somchit, Muhammad Nazrul (2015) In vivo antitrypanosomal activity of Garcinia hombroniana aqueous extract. Research in Veterinary Science, 100. pp. 226-231. ISSN 0034-5288; ESSN: 1532-2661


The anti-Trypanosoma evansi activity of Garcinia hombroniana (seashore mangosteen) leaves aqueous extract was tested on experimentally infected Sprague–Dawley rats. Treatment of infected rats with G. hombroniana extract resulted in a significantly extended post-infection longevity (p < 0.05), compared to the untreated control group. The possible mode of antitrypanosomal effect of the plant extract was also investigated on cultured T. evansi in HMI-9 medium with the addition of 25 µg/ml G. hombroniana aqueous extract. It was observed that the addition of G. hombroniana extract resulted in the inhibition of trypanosomal kinetoplast division, with no significant inhibitory effect on nuclear division. It is concluded from the current study that the aqueous extract of G. hombroniana has a potential antitrypanosomal activity through the inhibition of kinetoplast division, as one of the possible mechanisms of its antitrypanosomal effect. This plant could serve as a possible source of new antitrypanosomal compounds.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1016/j.rvsc.2015.03.007
Publisher: Elsevier
Keywords: Garcinia hombroniana; Trypanosoma evansi; Trypanosomiasis; Surra
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 16 Apr 2021 02:56
Last Modified: 16 Apr 2021 02:56
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.rvsc.2015.03.007
URI: http://psasir.upm.edu.my/id/eprint/45114
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