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Anti breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice


Citation

Saiful Yazan, Latifah and Yong, Sze Ong and Zaaba, Nur Elena and Mohd Ali, Razana and Jhi, Biau Foo and Yin, Sim Tor (2015) Anti breast cancer properties and toxicity of Dillenia suffruticosa root aqueous extract in BALB/c mice. Asian Pacific Journal of Tropical Biomedicine, 5 (12). pp. 1018-1026. ISSN 2221-1691

Abstract

Objective To determine the anti-breast cancer activities and the safety oral consumption of Dillenia suffruticosa root aqueous extract (DRAE) in BALB/c mice. Methods In the anti-breast cancer study, female BALB/c mice were divided into five groups (n = 12), which were (1) positive control (with breast cancer, untreated), (2) negative control (without breast cancer, untreated) and other three groups of mice with breast cancer treated with 1 000, 500 and 250 mg/kg of DRAE, respectively, by oral gavage for 28 days. All mice except from the negative control group were injected into the mammary fat pad with 4T1 cells (1 × 105 4T1 cells/0.1 mL of phosphate buffer solution). DRAE was administered orally on Day 11 after the tumor has developed. Results The tumor volume of the 1 000 mg/kg of DRAE group reduced significantly compared to the positive control while treatment with 500 mg/kg of DRAE had significantly inhibited metastasis to the heart. In the acute toxicity study, treatment with up to 5 000 mg/kg of DRAE was not toxic to the animals, indicating its safety when a large amount of this plant extract was ingested. Based on the sub-acute toxicity study, treatment of the highest dose of DRAE (1 000 mg/kg) had mild liver toxicity indicated by mild focal hemorrhage. Conclusions DRAE possesses anti-breast cancer properties but at the same time it shows mild toxicity to the liver. The non observable adverse effect dose for DRAE is 500 mg/kg.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1016/j.apjtb.2015.09.008
Publisher: Asian Pacific Journal of Tropical Biomedicine Editorial Office
Keywords: Dillenia suffruticosa; 4T1 Tumor-bearing mice; Breast cancer; Toxicity
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 21 Sep 2016 02:48
Last Modified: 21 Sep 2016 02:48
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.apjtb.2015.09.008
URI: http://psasir.upm.edu.my/id/eprint/43781
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