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Absorption and bioavailability of nano-size reduced calcium citrate fortified milk powder in ovariectomized and ovariectomized-osteoporosis rats


Citation

Erfanian, Arezoo and Mirhosseini, Hamed and Rasti, Babak and Bejo, Mohd Hair and Mustafa, Shuhaimi and Abd Manap, Mohd Yazid (2015) Absorption and bioavailability of nano-size reduced calcium citrate fortified milk powder in ovariectomized and ovariectomized-osteoporosis rats. Journal of Agricultural and Food Chemistry, 63 (24). pp. 5795-5804. ISSN 0021-8561

Abstract / Synopsis

The aim of this study was to evaluate the effects of fortification and nano-size reduction on calcium absorption and bioavailability of milk powder formula in sham, ovariectomized, and ovariectomized-osteoporosis rats as a menopause and menopause-osteoporosis model. Skim milk powder and skim milk powder fortified with calcium citrate and the suitable doses of inulin, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamins D3, K1, and B6 were formulated based on the North American and Western European recommended dietary allowances. Optimization on cycle and pressure of high-pressure homogenizer was done to produce nano-fortified milk powder. In vivo study demonstrated that fortification and calcium citrate nano-fortified milk powder increased absorption and bioavailability of calcium, as well as bone stiffness and bone strength in sham, ovariectomized, and ovariectomized-osteoporosis rats. This study successfully developed an effective fortified milk powder for food application.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Veterinary Medicine
Halal Products Research Institute
DOI Number: https://doi.org/10.1021/acs.jafc.5b01468
Publisher: American Chemical Society
Keywords: Calcium absorption; Calcium bioavailability; Fortified milk; In vivo study; Menopause; Nanoparticle; Osteoporosis
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 22 Jul 2016 10:33
Last Modified: 22 Jul 2016 10:33
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1021/acs.jafc.5b01468
URI: http://psasir.upm.edu.my/id/eprint/43631
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