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A new coumarin from stem bark of Mesua hexapetala


Karunakaran, Thiruventhan and Ee, Gwendoline Cheng Lian and Teh, Soek Sin and Daud, Shaari and Mah, Siau Hui and Lim, Chan Kiang and Jong, Vivien Yi Mian and Awang, Khalijah (2016) A new coumarin from stem bark of Mesua hexapetala. Natural Product Research, 30 (14). pp. 1591-1597. ISSN 1478-6419; ESSN: 1478-6427


A new alkylated coumarin derivative, hexapetarin (1) along with three other xanthones, trapezifolixanthone (2), cudraxanthone G (3) and 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4), and four common triterpenoids, friedelin (5), stigmasterol (6), beta-sitosterol (7) and gamma-sitosterol (8) were isolated from the stem bark of Mesua hexapetala (Clusiaceae), a plant, native to Malaysia. The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. Anti-inflammatory activity assay indicated hexapetarin (1) to possess moderate anti-inflammatory activity, while 1,3,7-trihydroxy-2,4-di (3-methyl-2-butenyl)xanthone (4) gave very good activity.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
DOI Number: https://doi.org/10.1080/14786419.2015.1120727
Publisher: Taylor & Francis
Keywords: Mesua hexapetala; Anti-inflammatory; Coumarin; Xanthone
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 29 Jun 2016 02:44
Last Modified: 30 Nov 2016 01:13
Altmetrics: httphttp://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/14786419.2015.1120727
URI: http://psasir.upm.edu.my/id/eprint/43523
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