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A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency


Chiou, Perng Lee and Khalid, Bahariah (2015) A case series of acquired haemophilia in a Malaysian hospital: unpredictabty rare medical emergency. Oxford Medical Case Reports, 2015 (10). pp. 330-332. ISSN 2053-8855


Acquired haemophilia (AH) is a rare bleeding disorder characterized by the presence of acquired inhibitors against Factor VIII causing disruption of coagulation cascade. It has no known genetic inheritance, and diagnosis remains a challenge. The peculiar presentations are later age of onset as acute pain in weight-bearing joints and spontaneous muscle haematoma with isolated prolonged activated partial thrombin time (APTT). Prevalence is 1 per million per year affecting both genders equally where blood product transfusion is seen in almost 87% of cases. The direct cause of AH is still unknown, and autoimmune dysregulation has been postulated, which predisposes to the development of the factor inhibitors. Being extremely rare, we are reporting two consecutive patients diagnosed by unusual bleeding episodes with isolated prolonged APTT due to Factor VIII inhibitors. AH deserves a special mention as high index of suspicion is required. More studies are required to provide better guidance in diagnosis and management of this condition.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1093/omcr/omv055
Publisher: Oxford University Press
Keywords: Haemophilia; Haematoma
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 28 Jun 2016 03:35
Last Modified: 28 Jun 2016 03:35
Altmetrics: http://www.almetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1093/omcr/omv055
URI: http://psasir.upm.edu.my/id/eprint/43462
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