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Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM)


Citation

Yusoff, Khatijah and Tan, Wen Siang and Lau, Chin Hoon and Ng, Ban Kim and Ibrahim, Abdul Latif (1996) Sequence of the haemagglutinin-neuraminidase gene of the Newcastle disease virus oral vaccine strain V4(UPM). Avian Pathology, 25 (4). pp. 837-844. ISSN 0307-9457; ESSN: 1465-3338

Abstract / Synopsis

The nucleotide sequence of the haemagglutinin‐neuraminidase (HN) glycoprotein gene of Newcastle disease virus (NDV) variant strain V4(UPM) was determined by direct genomic RNA sequencing and confirmed by cycle sequencing. The gene comprises 1996 nucleotides encoding a 615 amino acid protein of size 67.4 kDa. The nucleotide and amino acid sequences of this strain were compared with those of the parent strain V4(QUE). There are 16 nucleotide substitutions on V4(UPM), eight of which are silent mutations and another eliminated a potential Asn‐linked glycosylation site in V4(UPM). In addition, an Arg (403) residue was shown to be absent in the variant strain. This deletion is thought to be significant because of its location in a highly conserved region of the HN protein.


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Additional Metadata

Item Type: Article
Divisions: Universiti Pertanian Malaysia
DOI Number: https://doi.org/10.1080/03079459608419185
Publisher: Houghton Trust
Keywords: Haemagglutinin-neuraminidase (HN); Newcastle disease virus (NDV); V4(UPM)
Depositing User: Nabilah Mustapa
Date Deposited: 13 Apr 2016 11:31
Last Modified: 13 Apr 2016 11:31
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/03079459608419185
URI: http://psasir.upm.edu.my/id/eprint/42345
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