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The responses by gut-associated and bronchus-associated lymphoid tissues of buffalo calves following oral exposure to Pasteurella multocida B:2


Citation

Abubakar, Muhammad Salisu and Saad, Mohd Zamri and Sabri, Jasni and Abu Bakar @ Zakaria, Md Zuki (2014) The responses by gut-associated and bronchus-associated lymphoid tissues of buffalo calves following oral exposure to Pasteurella multocida B:2. Pertanika Journal of Tropical Agricultural Science, 37 (2). pp. 215-221. ISSN 1511-3701; ESSN: 2231-8542

Abstract / Synopsis

This report describes the mucosal immune response in the gastro-intestinal and respiratory tracts of buffalo calves following oral exposure to live wild-type Pasteurella multocida B:2. Nine buffalo calves of approximately 8 months old were treated with intramuscular injections of dexamethasone for 3 consecutive days before they were divided into 3 groups. Calves of group 1 were exposed orally to 50 ml inoculums containing 109 colony forming units (CFU)/ml of live wild-type P. multocida B:2. Calves of group 2 were exposed intratrachea with 5ml of the same inocula while calves of group 3 were given 50ml of PBS orally. At the end of day 7 post-exposure, all surviving calves were killed and organs of gastrointestinal and respiratory tracts were processed for histology examination. The presence of lymphoid nodules, the size of the nodules and the number of lymphocytes were noted. Both oral and intra-trachea exposures elicited mucosal responses in both gastro-intestinal and respiratory tracts. Oral exposure stimulated significantly (p <0.05) superior mucosalresponse in the gastrointestinal tract, while intratracheal exposure stimulated significantly (p<0.05) superior mucosal response in the respiratory tract. Overall, oral exposure was ableto stimulate the distance mucosal sites such as the respiratory tract and provides potential use for oral administration of live vaccine against haemorrhagic septicaemia.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Universiti Putra Malaysia Press
Keywords: Mucosal immunity, oral administration; Gastro-intestinal tract; Respiratory tract; Pasteurella multocida B:2; Buffalo calves
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 10 Feb 2016 05:22
Last Modified: 18 Nov 2016 08:54
URI: http://psasir.upm.edu.my/id/eprint/41800
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