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Protective effects of defatted dabai peel extracts in hypercholesterolemic rabbits based on histopathological methods


Citation

Khoo, Hock Eng and Azlan, Azrina and Ismail, Amin and Al-Sheraji, Sadek Hassan (2015) Protective effects of defatted dabai peel extracts in hypercholesterolemic rabbits based on histopathological methods. Malaysian Journal of Medicine and Health Sciences, 11 (2). pp. 59-68. ISSN 1675-8544

Abstract

Defatted dabai peel contains a high amount of anthocyanin. Anthocyanins are known to prevent several types of disease, including cardiovascular-related complications. This study aimed to describe the effects of different doses of defatted dabai peel extract by histopathological analyses on lesions in the liver, kidney, heart and aorta. Histopathology methods were applied to determine the protective effects of defatted dabai peel extracts against hypercholesterolemia-induced oxidative damages to animal organs. Haematoxylin and eosin staining was applied for histopathology examination for liver, kidney, heart and aorta. Data showed that a high dose of defatted dabai extract (3000 mg per day) applied to hypercholesterolemic rabbits for eight weeks had mild protective effect, especially reducing the severity of hepatic fibrosis and steatosis of the renal medulla. The high dose of extract supplementation also reduced inflammation of aorta and formation of atherosclerosis plaque in the cell wall of right ventricle of the heart. The high dose of defatted dabai peel extract could be a protective agent against oxidative stress.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Dabai; Extract; Histopathology; Hypercholesterolemic; Organ
Depositing User: Mohd Hafiz Che Mahasan
Date Deposited: 01 Feb 2016 07:02
Last Modified: 01 Feb 2016 07:02
URI: http://psasir.upm.edu.my/id/eprint/41699
Statistic Details: View Download Statistic

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