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Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens


Abd Rahman, Yasmin and Bejo, Mohd Hair and Kaiser, Pete and Fakurazi, Sharida and Omar, Abdul Rahman (2013) Involvement of splenic dendritic cells during infectious bursal disease virus infection in chickens. In: World’s Poultry Science Association (Malaysia Branch) and World Veterinary Poultry Association (Malaysia Branch) Scientific Conference 2013, 30 Nov.-1 Dec. 2013, Faculty of Veterinary Medicine, Universiti Putra Malaysia. (pp. 128-129).

Abstract / Synopsis

Infectious bursal disease virus (IBDV) is attracted to lymphoid cells and especially those of B-lymphocyte origins. Recent studies have shown that IBDV also can infect macrophage. However, the involvement of dendritic cells (DC) in IBDV infection is not clear. The objective of this study was to examine the effect IBDV vaccine and very virulent (vv) strains on avian derived splenic DC. Enriched DCs were cultured from spleen of infected SPF chickens with vaccine and vvIBDV strains of IBDV. The infected DCs were analysed for morphology study, immunophenotyping, proliferation activity, and immunofluorescent antibody test (IFAT). Both IBDV strains inhibit DC proliferation. However, the inhibition is higher in vvIBDV strain group. However, the expressions of IBDV antigens from both strains were detected in splenic DC.

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Additional Metadata

Item Type: Conference or Workshop Item (Poster)
Divisions: Faculty of Veterinary Medicine
Institute of Bioscience
Publisher: Faculty of Veterinary Medicine
Keywords: Dendritic Cells; Infectious Bursal Disease Virus; Vaccine; vvIBDV
Depositing User: Erni Suraya Abdul Aziz
Date Deposited: 17 Nov 2015 10:07
Last Modified: 28 Jan 2016 10:06
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