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In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract


Citation

Yeap, Swee Keong and Liang, Woon San and Beh, Boon Kee and Ho, Wan Yong and Noaman, Yousr Abdulhadi and Mohammed Alitheen, Noorjahan Banu (2013) In vivo antidiabetic and acute toxicity of spray-dried Vernonia amygdalina water extract. International Food Research Journal, 20 (2). pp. 613-616. ISSN 1985-4668; ESSN: 2231-7546

Abstract

The spray-dried Vernonia amygdalina water extract was evaluated for antidiabetic effect using normoglycaemic, glucose induced hyperglycaemic and streptozotocin induced diabetic mice. This effect was compared with an oral dose of Momordica charantia. Besides, acute toxicity of the extract was also evaluated at concentration 2000 and 5000 mg/kg body weight. The extract was able to reduce blood glucose level in glucose and streptozotocin induced hyperglycaemic mice without causing hypoglycemic effect on fasting normoglycaemic mice. Moreover, mice appeared to be normal and no mortality was observed in the acute toxicity study after treated with up to 5000mg/kg of extract. These results indicated that the spray-dried Vernonia amygdalina water extract was a potential antidiabetic agent which does not induce hypoglycemic and acute toxicity on normal subject.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
Publisher: Faculty of Food Science and Technology, Universiti Putra Malaysia
Keywords: Acute toxicity; Antidiabetic; In vivo; Vernonia amygdalina
Depositing User: Najah Mohd Ali
Date Deposited: 10 Dec 2015 02:13
Last Modified: 10 Dec 2015 02:13
URI: http://psasir.upm.edu.my/id/eprint/41060
Statistic Details: View Download Statistic

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