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The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats


Citation

Mohd Mokhtar, Ruzaidi Azli and Ismail, Amin and Abdul Ghani, Nawalyah and Hamid, Muhajir and H. A., Faizul (2005) The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats. Journal of Ethnopharmacology, 98 (1-2). pp. 55-60. ISSN 0378-8741; ESSN: 1872-7573

Abstract / Synopsis

The present study aims to investigate the effect of cocoa extract on serum glucose levels and lipid profiles in streptozotocin-diabetic rats. Cocoa extract (contained 285.6 mg total polyphenol per gram extract) was prepared from fermented and roasted (140 °C, 20 min) beans by extracting using 80% ethanol in the ratio of 1–10. The extract of three dosages (1, 2, and 3%) was fed to normal and diabetic rats for a period of 4 weeks. In hyperglycaemic group, cocoa extract (1 and 3%) diets were found to significantly lower (p < 0.05) the serum glucose levels compared to the control. Furthermore, supplementation of 1 and 3% cocoa extract had significantly reduced (p < 0.05) the level of total cholesterol in diabetic rats. In addition, 1, 2, and 3% cocoa extract diets had significantly lowered (p < 0.05) the total triglycerides. Interestingly, this study found that serum HDL-cholesterol had increased significantly (p < 0.05) in diabetic rats fed with 2% cocoa extract, while the LDL-cholesterol had decreased significantly (p < 0.05) in the 1% treated group. These results indicate that cocoa extract may possess potential hypoglycaemic and hypocholestrolemic effects on serum glucose levels and lipid profiles, respectively. The results also found that the effect of cocoa extract was dose-dependent.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Science and Environmental Studies
DOI Number: https://doi.org/10.1016/j.jep.2004.12.018
Publisher: Elsevier
Keywords: Cocoa extract; Glucose levels; Lipid profiles; Hypoglycaemic; Hypocholestrolemic
Depositing User: Nabilah Mustapa
Date Deposited: 17 Sep 2015 09:08
Last Modified: 17 Sep 2015 09:08
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.jep.2004.12.018
URI: http://psasir.upm.edu.my/id/eprint/40318
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