Citation
Abstract
Methanol extracts of seven Malaysian medicinal plants were screened for antioxidant and nitric oxide inhibitory activities. Antioxidant activity was measured by using FTC, TBA and DPPH free radical scavenging methods and Griess assay was used for the measurement of nitric oxide inhibition in lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-treated RAW 264.7 cells. All the extracts showed strong antioxidant activity comparable to or higher than that of α-tocopherol, BHT and quercetin in FTC and TBA methods. The extracts from Leea indica and Spermacoce articularis showed strong DPPH free radical scavenging activity comparable with quercetin, BHT and Vit C. Spermacoce exilis showed only moderate activity but other species were weak as compared to the standards. In the Griess assay Lasianthus oblongus, Chasalia chartacea, Hedyotis verticillata, Spermacoce articularis and Leea indica showed strong inhibitory activity on nitric oxide production in LPS and IFN-γ-induced RAW 264.7 cells. Extracts from Psychotria rostrata and Spermacoce exilis also inhibited NO production but this was due to their cytotoxic effects upon cells during culture.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Faculty of Science Institute of Bioscience |
| DOI Number: | https://doi.org/10.1016/j.jep.2004.03.007 |
| Publisher: | Elsevier |
| Keywords: | Medicinal plants; Antioxidant activity; Nitric oxide inhibition |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 17 Sep 2015 00:47 |
| Last Modified: | 17 Sep 2015 00:47 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.jep.2004.03.007 |
| URI: | http://psasir.upm.edu.my/id/eprint/40232 |
| Statistic Details: | View Download Statistic |
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