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High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)


Citation

Song, Jae Hoon and Jung, Sook In and Ko, Kwan Soo and Kim, Na Young and Son, Jun Seong and Chang, Hyun Ha and Ki, Hyun Kyun and Oh, Won Sup and Suh, Ji Yoeun and Peck, Kyong Ran and Lee, Nam Yong and Yang, Yonghong and Lu, Quan and Chongthaleong, Anan and Chiu, Cheng Hsun and Lalitha, Mukkai Kesavan and Perera, Jennifer A. and Yee, Ti Teow and Kumarasinghe, Gamini and Jamal, Farida and Kamarulzaman, Adeeba and Parasakthi, Navaratnam and Van Hung, Pham and Carlos, Celia Carpio and So, Thomas Man-Kit and Ng, Tak Keung and Shibl, Atef M. (2004) High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study). Antimicrobial Agents and Chemotherapy, 48 (6). pp. 2101-2107. ISSN 0066-4804; ESSN: 1098-6596

Abstract

A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4%) were not susceptible to penicillin, 23% were intermediate, and 29.4% were penicillin resistant (MICs ≥ 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4%), followed by those from Korea (54.8%), Hong Kong (43.2%), and Taiwan (38.6%). The penicillin MICs at which 90% of isolates are inhibited (MIC90s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1%), Taiwan (86%), Korea (80.6%), Hong Kong (76.8%), and China (73.9%). The MIC90s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8%), followed by isolates from Sri Lanka (9.5%), the Philippines (9.1%), and Korea (6.5%). Multilocus sequence typing showed that the spread of the Taiwan19F clone and the Spain23F clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1128/AAC.48.6.2101-2107.2004
Publisher: American Society for Microbiology
Keywords: Streptococcus pneumoniae; Asia; Antimicrobial resistance
Depositing User: Nabilah Mustapa
Date Deposited: 27 Aug 2015 01:10
Last Modified: 27 Aug 2015 01:10
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1128/AAC.48.6.2101-2107.2004
URI: http://psasir.upm.edu.my/id/eprint/40040
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