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Antioxidative activity of carbazoles from Murraya koenigii leaves


Tachibana, Yukari and Kikuzaki, Hiroe and Lajis, Nordin and Nakatani, Nobuji (2001) Antioxidative activity of carbazoles from Murraya koenigii leaves. Journal of Agricultural and Food Chemistry, 49 (11). pp. 5589-5594. ISSN 0021-8561; ESSN: 1520-5118


The antioxidative properties of the leaves extracts of Murraya koenigii using different solvents were evaluated based on the oil stability index (OSI) together with their radical scavenging ability against 1-1-diphenyl-2-picrylhydrazyl (DPPH). The methylene chloride (CH2Cl2) extract and the ethyl acetate (EtOAc) soluble fraction of the 70% acetone extract significantly prolonged the OSI values comparable to those of α-tocopherol and BHT. Five carbazole alkaloids were isolated from the CH2Cl2 extract and their structures were identified to be euchrestine B (1), bismurrayafoline E (2), mahanine (3), mahanimbicine (4), and mahanimbine (5) based on 1H and 13C NMR and mass (MS) spectral data. The OSI value of carbazoles at 110 °C decreased in the order 1 and 3 > α-tocopherol > BHT > 2 > 4, 5 and control. It is assumed that compounds 1 and 3 contributed to the high OSI value of the CH2Cl2 extract of M. koenigii. The DPPH radical scavenging activity for these carbazoles was in the order ascorbic acid > 2 > 1, 3 and α-tocopherol > BHT > 4 and 5.

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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
DOI Number: https://doi.org/10.1021/jf010621r
Publisher: American Chemical Society
Keywords: Carbazole; Murraya koenigii; Curry leaf; Antioxidant; Oil stability index (OSI); 1-1-diphenyl-2-picrylhydrazyl (DPPH)
Depositing User: Nabilah Mustapa
Date Deposited: 26 Aug 2015 02:57
Last Modified: 26 Aug 2015 02:57
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1021/jf010621r
URI: http://psasir.upm.edu.my/id/eprint/39980
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