Citation
Karunanidhi, Arunkumar and Ghaznavi-Rad, Ehsanollah and Jeevajothi Nathan, Jayakayatri and Sither Joseph Vesudian, Narcisse Mary and Chigurupati, Sridevi and Mohd Fauzi, Fazlin and Pichika, Mallikarjuna Rao and Awang Hamat, Rukman and Than, Leslie Thian Lung and Van Belkum, Alex and Neela, Vasantha Kumari
(2019)
Bioactive 2-(methyldithio)pyridine-3-carbonitrile from Persian shallot (Allium stipitatum Regel.) exerts broad-spectrum antimicrobial activity.
Molecules, 24 (6).
art. no. 1003.
pp. 1-12.
ISSN 1420-3049
Abstract
Antibiotic resistance is a problem that continues to challenge the healthcare sector, especially in clinically significant pathogens like methicillin-resistant Staphylococcus aureus (MRSA). Herein is described the isolation and structure elucidation of a bioactive compound from Allium stipitatum with antimicrobial activity. Crude Allium stipitatum dichloromethane extract (ASDE) was subjected to systematic purification by chromatographic procedures to afford various bioactive fractions. A fraction that exhibited anti-MRSA activity (4 µg·mL−1) was further characterized to determine the structure. The structure of the compound was elucidated as 2-(methyldithio)pyridine-3-carbonitrile (2-Medpy-3-CN). The 2-Medpy-3-CN compound, which was screened for antimicrobial activity, exhibited minimum inhibitory concentrations (MICs) in the range of 0.5 to >64 µg·mL−1 for tested bacterial species and 0.25 to 2 µg·mL−1 for Candida spp. Further studies are important to confirm the drug target and mechanism of action.
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