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Empowering mesenchymal stem cells for ocular degenerative disorders


Ding, Shirley Suet Lee and Subbiah, Suresh Kumar and Khan, Mohammed Safwan Ali and Farhana, Aisha and Mok, Pooi Ling (2019) Empowering mesenchymal stem cells for ocular degenerative disorders. International Journal of Molecular Sciences, 20 (7). art. no. 1784. pp. 1-13. ISSN 1661-6596; ESSN: 1422-0067


Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and optic neuritis. Despite the known therapeutic role and mechanisms of MSCs, low cell precision towards the targeted area and cell survivability at tissue needing repair often resulted in a disparity in therapeutic outcomes. In this review, we will discuss the current and feasible strategy options to enhance treatment outcomes with MSC therapy. We will review the application of various types of biomaterials and advances in nanotechnology, which have been employed on MSCs to augment cellular function and differentiation for improving treatment of visual functions. In addition, several modes of gene delivery into MSCs and the types of associated therapeutic genes that are important for modulation of ocular tissue function and repair will be highlighted.

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Official URL or Download Paper: https://www.mdpi.com/1422-0067/20/7/1784

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/ijms20071784
Publisher: MDPI
Keywords: Mesenchymal stem cells; Ocular disorders; Degeneration
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:28
Last Modified: 04 May 2020 16:28
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms20071784
URI: http://psasir.upm.edu.my/id/eprint/38403
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