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Centella asiatica protects D-galactose/AlCl3 mediated Alzheimer's disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus


Chiroma, Samaila Musa and Baharuldin, Mohamad Taufik Hidayat and Mat Taib, Che Norma and Amom, Zulkhairi and Jagadeesan, Saravanan and Adenan, Mohd Ilham and Mahdi, Onesimus and Mohd Moklas, Mohamad Aris (2019) Centella asiatica protects D-galactose/AlCl3 mediated Alzheimer's disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus. International Journal of Molecular Sciences, 20 (8). art. no. 1871. pp. 1-14. ISSN 1661-6596; ESSN: 1422-0067


Alzheimer’s disease (AD) is a progressive neurodegenerative disorder more prevalent among the elderly population. AD is characterised clinically by a progressive decline in cognitive functions and pathologically by the presence of neurofibrillary tangles (NFTs), deposition of beta-amyloid (Aβ) plaque and synaptic dysfunction in the brain. Centella asiatica (CA) is a valuable herb being used widely in African, Ayurvedic, and Chinese traditional medicine to reverse cognitive impairment and to enhance cognitive functions. This study aimed to evaluate the effectiveness of CA in preventing d-galactose/aluminium chloride (d-gal/AlCl3) induced AD-like pathologies and the underlying mechanisms of action were further investigated for the first time. Results showed that co-administration of CA to d-gal/AlCl3 induced AD-like rat models significantly increased the levels of protein phosphatase 2 (PP2A) and decreased the levels of glycogen synthase kinase-3 beta (GSK-3β). It was further observed that, CA increased the expression of mRNA of Bcl-2, while there was minimal effect on the expression of caspase 3 mRNA. The results also showed that, CA prevented morphological aberrations in the connus ammonis 3 (CA 3) sub-region of the rat’s hippocampus. The results clearly demonstrated for the first time that CA could alleviate d-gal/AlCl3 induced AD-like pathologies in rats via inhibition of hyperphosphorylated tau (P-tau) bio-synthetic proteins, anti-apoptosis and maintenance of cytoarchitecture.

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Official URL or Download Paper: https://www.mdpi.com/1422-0067/20/8/1871

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3390/ijms20081871
Publisher: MDPI
Keywords: Alzheimer's disease; Centella asiatica; Hippocampus; Protein poshophatase 2; Glycogen synthase kinase 3; B-cell lymphoma 2
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:28
Last Modified: 04 May 2020 16:28
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms20081871
URI: http://psasir.upm.edu.my/id/eprint/38397
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