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Carotenoids: how effective are they to prevent age-related diseases?


Tan, Bee Ling and Mohd Esa, Norhaizan (2019) Carotenoids: how effective are they to prevent age-related diseases? Molecules, 24 (9). art. no. 1801. pp. 1-23. ISSN 1420-3049


Despite an increase in life expectancy that indicates positive human development, a new challenge is arising. Aging is positively associated with biological and cognitive degeneration, for instance cognitive decline, psychological impairment, and physical frailty. The elderly population is prone to oxidative stress due to the inefficiency of their endogenous antioxidant systems. As many studies showed an inverse relationship between carotenoids and age-related diseases (ARD) by reducing oxidative stress through interrupting the propagation of free radicals, carotenoid has been foreseen as a potential intervention for age-associated pathologies. Therefore, the role of carotenoids that counteract oxidative stress and promote healthy aging is worthy of further discussion. In this review, we discussed the underlying mechanisms of carotenoids involved in the prevention of ARD. Collectively, understanding the role of carotenoids in ARD would provide insights into a potential intervention that may affect the aging process, and subsequently promote healthy longevity.

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Official URL or Download Paper: https://www.mdpi.com/1420-3049/24/9/1801

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.3390/molecules24091801
Publisher: MDPI
Keywords: Aging; Cancer; Cardiovascular disease; Dementia; Diabetes; Inflammation; Oxidative stress
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:24
Last Modified: 04 May 2020 16:24
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules24091801
URI: http://psasir.upm.edu.my/id/eprint/38371
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