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Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer


Paulraj, Felicia Simone and Abas, Faridah and Lajis, Nordin and Othman, Iekhsan and Naidu, Rakesh (2019) Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer. Biomolecules, 9 (7). art. no. 270. pp. 1-14. ISSN 2218-273X


While curcumin has a range of therapeutic benefits, its potent anticancer activity remains an attractive avenue for anticancer research owing to the multifactorial nature of cancer itself. The structure of curcumin has thus been used as a lead to design more potent analogues, and diarylpentanoids in particular have shown improved cytotoxicity over curcumin. Investigations of diarylpentanoids have demonstrated that these compounds exert anti-cancer effects through several signalling pathways that are associated with cancer. This review focuses on selected diarylpentanoids and highlights molecular targets that modulate key pathways involved in cancer such as NF-κB, MAPK/ERK, and STAT signalling. Future research will need to focus on drug interactions to explore potential synergistic actions of diarylpentanoids and further establish the use of diverse animal models.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Science
DOI Number: https://doi.org/10.3390/biom9070270
Publisher: MDPI
Keywords: Diarylpentanoid; Curcumin; Anticancer activity; Molecular pathway; Cancer
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:18
Last Modified: 04 May 2020 16:18
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/biom9070270
URI: http://psasir.upm.edu.my/id/eprint/38331
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