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Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens


Mahizan, Nik Nur Amirah and Yang, Shun Kai and Moo, Chew Li and Song, Adelene Ai Lian and Chong, Chou Min and Chong, Chun Wie and Abushelaibi, Aisha and Lim, Erin Swee Hua and Lai, Kok Song (2019) Terpene derivatives as a potential agent against antimicrobial resistance (AMR) pathogens. Molecules, 24 (14). art. no. 2631. pp. 1-21. ISSN 1420-3049


The evolution of antimicrobial resistance (AMR) in pathogens has prompted extensive research to find alternative therapeutics. Plants rich with natural secondary metabolites are one of the go-to reservoirs for discovery of potential resources to alleviate this problem. Terpenes and their derivatives comprising of hydrocarbons, are usually found in essential oils (EOs). They have been reported to have potent antimicrobial activity, exhibiting bacteriostatic and bactericidal effects against tested pathogens. This brief review discusses the activity of terpenes and derivatives against pathogenic bacteria, describing the potential of the activity against AMR followed by the possible mechanism exerted by each terpene class. Finally, ongoing research and possible improvisation to the usage of terpenes and terpenoids in therapeutic practice against AMR are discussed.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.3390/molecules24142631
Publisher: MDPI
Keywords: Terpenes; Terpenoids; Antimicrobial resistance; Synergy
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:13
Last Modified: 04 May 2020 16:13
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules24142631
URI: http://psasir.upm.edu.my/id/eprint/38297
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