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Choline-based ionic liquids as media for the growth of Saccharomyces cerevisiae


Sivapragasam, Magaret and Wilfred, Cecilia Devi and Jaganathan, Joshua Raj and Krishnan, Sooridarsan and Wan Ab. Karim Ghani, Wan Azlina (2019) Choline-based ionic liquids as media for the growth of Saccharomyces cerevisiae. Processes, 7 (7). art. no. 471. pp. 1-13. ISSN 2227-9717


Ionic liquids (ILs) have garnered great attention as alternative solvents in many biological reactions and applications. However, its unknown toxicity is in line with the challenges to use it for biological applications. In this study, three choline based Ionic Liquids—choline saccharinate (CS), choline dihydrogen phosphate (CDHP), and choline tryptophanate (CT) were assessed for their suitability on the growth of Saccharomyces cerevisiae. The ILs were incorporated into the growth media of S. cerevisiae (defined as synthetic media) to access its potential as a substitute to conventional media. The compatibility of the synthetic media was evaluated based on the toxicity (EC50), growth curve, and glucose profile. The results showed that the incorporation of CDHP and CS did promote the growth of S. cerevisiae with a rapid glucose consumption rate. The growth of S. cerevisiae with the media composition of yeast extract, peptone, and CS showed improvement of 13%. We believe that these observations have implications in the biocompatibility studies of ILs to microorganisms.

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Official URL or Download Paper: https://www.mdpi.com/2227-9717/7/7/471

Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.3390/pr7070471
Publisher: MDPI
Keywords: Biotoxicity; Choline; Ionic liquids; Saccharomyces cerevisiae
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:13
Last Modified: 04 May 2020 16:13
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/pr7070471
URI: http://psasir.upm.edu.my/id/eprint/38296
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