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The regulatory role of microRNAs in breast cancer


Citation

Loh, Hui Yi and Norman, Brendan P. and Lai, Kok Song and Nik Abd Rahman, Nik Mohd Afizan and Mohammed Alitheen, Noorjahan Banu and Osman, Mohd Azuraidi (2019) The regulatory role of microRNAs in breast cancer. International Journal of Molecular Sciences, 20 (19). art. no. 4940. pp. 1-27. ISSN 1661-6596; ESSN: 1422-0067

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules which function as critical post-transcriptional gene regulators of various biological functions. Generally, miRNAs negatively regulate gene expression by binding to their selective messenger RNAs (mRNAs), thereby leading to either mRNA degradation or translational repression, depending on the degree of complementarity with target mRNA sequences. Aberrant expression of these miRNAs has been linked etiologically with various human diseases including breast cancer. Different cellular pathways of breast cancer development such as cell proliferation, apoptotic response, metastasis, cancer recurrence and chemoresistance are regulated by either the oncogenic miRNA (oncomiR) or tumor suppressor miRNA (tsmiR). In this review, we highlight the current state of research into miRNA involved in breast cancer, with particular attention to articles published between the years 2000 to 2019, using detailed searches of the databases PubMed, Google Scholar, and Scopus. The post-transcriptional gene regulatory roles of various dysregulated miRNAs in breast cancer and their potential as therapeutic targets are also discussed.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.3390/ijms20194940
Publisher: MDPI
Keywords: MicroRNAs; Breast cancer; oncomiR; tsmiR
Depositing User: Nabilah Mustapa
Date Deposited: 04 May 2020 16:06
Last Modified: 04 May 2020 16:06
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ijms20194940
URI: http://psasir.upm.edu.my/id/eprint/38241
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