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High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats


Citation

Tekeleselassie, A. W. and Rajion, Mohamed Ali and Goh, Yong Meng and Moteshakeri, M. and Farjam, Abdoreza Soleimani and Ebrahimi, Mahdi (2014) High-fat diets rich in n-3 polyunsaturated fatty acids delay onset of insulin resistance in rats. Pakistan Journal of Nutrition, 13 (4). pp. 223-233. ISSN 1680-5194; ESSN: 1994-7984

Abstract

Insulin resistance is a growing worldwide syndrome that predispose human to a number of chronic diseases such as diabetes and cardiovascular diseases. Various studies have indicated that insulin action is highly influenced by diet compositions particularly dietary fat intake and proportion of n-3 and n-6 Polyunsaturated Fatty Acids (PUFA). The current study was designed to assess the influence of High Fat Diet (HFD) with different n-6: n-3 Fatty Acid Ratios (FAR) on insulin sensitivity, plasma triacylglycerol (TAG) and lipoprotein profile. Forty male Sprague-Dawley rats were randomly allocated into four groups and received the isocaloric high fat diets enriched with either high n-6: n-3 fatty acid ratio (HFAR), medium n-6: n-3 fatty acid ratio (MFAR), low n-6: n-3 fatty acid ratio (LFAR) and compared with control rats fed standard chow (CTRL). The plasma insulin level of HFAR fed rats manifested significantly (P<0.05) higher concentration in most of the time points compared to the other groups. The corresponding insulin AUC (ng/L/120min) and insulin sensitivity index of HFAR fed rats appeared to be significantly higher (P<0.05) than CTRL (335.5±38.5), LFAR (273.7±37.6) and MFAR (265.9±21.7) groups. Blood lipid profile were found to be healthier in the LFAR and MFAR supplemented groups with significantly (P<0.05) lower total cholesterol and TAG levels. This study showed the possible protective effect against insulin resistance when low n-6: n-3 fatty acid ratio in high fat diets are applied in a rat model.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Veterinary Medicine
Institute of Tropical Agriculture
DOI Number: https://doi.org/10.3923/pjn.2014.223.233
Publisher: Asian Network for Scientific Information
Keywords: N-6: n-3 fatty acid ratio; Insulin sensitivity; Triacylglycerol; Total cholesterol; Insulin; Rat; Chronic diseases
Depositing User: Nabilah Mustapa
Date Deposited: 25 Sep 2015 01:41
Last Modified: 08 Dec 2015 01:20
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3923/pjn.2014.223.233
URI: http://psasir.upm.edu.my/id/eprint/37862
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