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Extended spectrum beta-lactamases: definition, classification and epidemiology


Ghafourian, Sobhan and Sadeghifard, Nourkhoda and Soheili, Sara and Sekawi, Zamberi (2015) Extended spectrum beta-lactamases: definition, classification and epidemiology. Current Issues in Molecular Biology, 17. pp. 11-22. ISSN 1467-3037; ESSN: 1467-3045


Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin. They are therefore effective against beta-lactam antibiotics such as ceftazidime, ceftriaxone, cefotaxime and oxyimino-monobactam. The objective of the current review is to provide a better understanding of ESBL and the epidemiology of ESBL producing organisms which are among those responsible for antibiotic resistant strains. Globally, ESBLs are considered to be problematic, particularly in hospitalized patients. There is an increasing frequency of ESBL in different parts of the world. The high risk patients are those contaminated with ESBL producer strains as it renders treatment to be ineffective in these patients. Thus, there an immediate needs to identify EBSL and formulate strategic policy initiatives to reduce their prevalence.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Caister Academic Press
Keywords: Extended spectrum beta-lactamases
Depositing User: Nabilah Mustapa
Date Deposited: 18 Dec 2015 01:52
Last Modified: 18 Dec 2015 01:52
URI: http://psasir.upm.edu.my/id/eprint/37589
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