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Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet


Citation

Mashmoul, Maryam and Azlan, Azrina and Mohd Yusof, Barakatun Nisak and Khaza'aid, Huzwah and Mohtarrudin, Norhafizah and Boroushaki, Mohammad Taher (2014) Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet. Journal of Functional Foods, 8. pp. 180-187. ISSN 1756-4646; ESSN: 2214-9414

Abstract / Synopsis

Overweight and obesity are the most common nutritional disorders in the world. The aim of this study was to evaluate anti-obesity effects of ethanolic extracts of saffron and crocin in comparison to orlistat in animal model. Male Sprague Dawley (SD) rats were fed high-fat diet (HFD) for 12 weeks to induce obesity. The saffron extracts (40 and 80 mg/kg), crocin (40 and 80 mg/kg) and orlistat (20 mg/kg) were fed to rats by mixing with high fat diet (HFD) for 8 weeks. Changes in anthropometrical, nutritional and lipid profile parameters were measured. The saffron extract significantly decreased food consumption in obese rats. Crocin (80 mg/kg) showed a significant decrease on rate of body weight gain, total fat pad and weight ratio of epididymal fat to body. Furthermore, crocin (80 mg/kg) significantly reduced plasma levels of triacylglycerol (TG) and total cholesterol (TC) while saffron extract (40 mg/kg) showed major improvement in low-density lipoprotein to high-density lipoprotein (LDL/HDL) level as atherogenic index. These findings demonstrated the potential anti-obesity benefits of saffron extract and crocin in preclinical study.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Halal Products Research Institute
DOI Number: https://doi.org/10.1016/j.jff.2014.03.017
Publisher: Elsevier
Keywords: Saffron; Crocin; Obesity; Weight loss; High-fat diet; Rat
Depositing User: Nabilah Mustapa
Date Deposited: 23 May 2015 18:45
Last Modified: 06 Oct 2015 11:40
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.jff.2014.03.017
URI: http://psasir.upm.edu.my/id/eprint/37390
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