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Effects of Centellaasiatica L., Curcuma longa L., and Strobilanthescrispus L. extracts on 3 kidney cell lines: in vitro cytotoxicity analysis


Citation

H., Hanisa and Mohd Lila, Mohd Azmi and Mohamed, Suhaila and Abdullah, Muhammad Nazrul Hakim (2014) Effects of Centellaasiatica L., Curcuma longa L., and Strobilanthescrispus L. extracts on 3 kidney cell lines: in vitro cytotoxicity analysis. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (suppl.2). pp. 388-392. ISSN 0975-1491

Abstract / Synopsis

Objective: This study was carried out to evaluate the in vitro cytotoxicity to three cell kidney lines by using the 3-(4, 5-d imethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (MTT) reduction assay of three popular medicinal plants used in Malaysia. Methods: Methanol and aqueous extracts of Centellaasiatica L., Strobilanthescrispus L. and Curcuma longa L. were tested at the non-toxic limit concentration at 50 (NTLC50) ranging from 50 µg/ml and 200 µg/ml depending on the cell lines used, i.e. African Green Monkey Kidney (Vero), Baby hamster Kidney (BHK) and Rabbit Kidney (RK) cells. Results: Centellaasiatica L. was the least toxic to the all cell lines tested followed by Strobilanthes crispus L. and Curcuma longa L. Methanol plant extracts inhibited cell growth but not to the aqueous plant extracts. Meanwhile, BHK cells were found to be the most resistant to the plant extracts. Conclusion: This study proves the safety of these plant extracts for future scientific studies in its biomedical properties.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Biotechnology
Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Halal Products Research Institute
Institute of Bioscience
Publisher: Innovare Academic Sciences
Keywords: Centella asiatica L.; Curcuma longa L.; Strobilanthes crispus L.; Cytotoxicity
Depositing User: Nabilah Mustapa
Date Deposited: 06 Aug 2015 16:02
Last Modified: 23 Aug 2016 16:51
URI: http://psasir.upm.edu.my/id/eprint/37340
Statistic Details: View Download Statistic

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