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Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae)


Md. Sukari, Mohd. Aspollah and Ismail, N. and Abu Bakar, Noor Haslizawati and Ithnin, Nur Liyana (2014) Cytotoxic carbazole alkaloids from Murraya koenigii (Rutaceae). Research Journal of Chemistry and Environment, 18 (11). pp. 8-11. ISSN 0972-0626; ESSN: 2278-4527


Crude extracts and isolated compounds from leaves, stem bark and roots of Murraya koenigii including (1) mahanimbine, (2) girinimbine, (3) murrayacine, (4) murrayanine, (5) murrayafoline A. and (6) 3-methylcarbazole were screened for cytotoxic activity against HL-60 cancer cell lines (human T-promyelocytic leukemia), MCF-7 cancer cell lines (human breast cancer), HT-29 cancer cell lines (human colon cancer) and HeLa cancer cell lines (human cervical carcinoma cancer). The cytotoxic potential of the isolated compounds was determined by using MTT (3-[4,5-dimethyl-2-thiazolyl]-2-5-diphenyl-2H-tetrazolium bromide) method. Most of the tested samples showed strong activity against four cancer cell lines with IC50 value less than 30 μg/ml.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Science
Keywords: Carbazole; Rutaceae; Murraya koenigii; Cytotoxic
Depositing User: Nabilah Mustapa
Date Deposited: 25 Jul 2015 03:53
Last Modified: 21 Oct 2015 04:38
URI: http://psasir.upm.edu.my/id/eprint/36954
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